🧪 GLP-3 Retatrutide 5mg: Metabolic Research Profile
GLP-3 Retatrutide 5mg is a synthetic 39-amino acid polypeptide precision-engineered for studies involving the simultaneous activation of GIP, GLP-1, and glucagon receptors.2 Researchers utilizing GLP-3 Retatrutide 5mg focus on its unique chimeric structure, which incorporates a C-20 fatty diacid moiety to enhance its stability and metabolic bioactivity in research settings.3
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Triple Receptor Affinity: The GLP-3 Retatrutide 5mg peptide is researched for its high affinity at GIP receptors (factor of 8.9) and potent agonism at both GLP-1 and GCG receptors.
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Glucagon Receptor Signaling: Unlike earlier dual agonists, GLP-3 Retatrutide 5mg allows for the study of glucagon-mediated energy expenditure and lipid oxidation pathways.4
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Enzymatic Stability: Featuring structural modifications that resist dipeptidyl peptidase-4 (DPP-4) degradation, GLP-3 Retatrutide 5mg facilitates an extended biological half-life of approximately 6 days in research models.
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Metabolic Flexibility: Laboratory evaluations of GLP-3 Retatrutide 5mg explore its ability to modulate hepatic fat content and stabilize glucose-dependent insulin secretion.
🔬 Key Research Applications of GLP-3 Retatrutide 5mg
This peptide is primarily used in laboratory models investigating:
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🧬 Synergistic Homeostasis: Studies on GLP-3 Retatrutide 5mg look at the effects of triple agonism on energy balance and metabolic markers compared to mono- or dual-agonists.
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🧠 Hypothalamic Signaling: Research into GLP-3 Retatrutide 5mg includes evaluations of the hypothalamic appetite centers and neuroplasticity in energy regulation models.
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🛡️ Hepatoprotective Research: Investigations into the biochemical properties of GLP-3 Retatrutide 5mg focus on liver fat reduction and markers of metabolic dysfunction-associated steatotic liver disease (MASLD).
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🫀 Cardiometabolic Dynamics: Evaluation of GLP-3 Retatrutide 5mg for its influence on vascular signaling and blood pressure stabilization in research analogs.
✅ GLP-3 Retatrutide 5mg Product Specifications
| Specification | Detail |
| Product Name | GLP-3 Retatrutide 5mg |
| Molecular Formula | C221H342N46O68 |
| Molecular Weight | 4731.33 g/mol |
| Concentration | 5 mg per vial |
| Appearance | Lyophilized white powder |
| Format | Lyophilized powder for reconstitution |
| Solubility | Freely soluble in water or PBS |
❄️ Product Care & Handling Guidelines
Proper storage is required to maintain the molecular integrity of the GLP-3 Retatrutide 5mg polypeptide.
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Unreconstituted (Powder): Store GLP-3 Retatrutide 5mg in a cool, dry environment. Long-term storage is optimal at -20°C to -80°C.
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Reconstituted (Liquid): Refrigerate GLP-3 Retatrutide 5mg at 2°C to 8°C immediately; researchers typically use within 14 to 30 days for maximum stability.
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Handling Note: Peptides like GLP-3 Retatrutide 5mg are sensitive to mechanical stress. Use gentle swirling during reconstitution; avoid vigorous shaking to prevent peptide denaturation.
📚 References & Resources
NCBI PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC11271400/
PubMed: https://pubmed.ncbi.nlm.nih.gov/40291085/
NCBI PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC12026077/
PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Retatrutide
NCBI PubMed: https://pubmed.ncbi.nlm.nih.gov/40741227//
⚠️ Laboratory Research Use Only Notice
The GLP-3 Retatrutide 5mg product is strictly intended for in vitro and non-clinical laboratory research purposes only. It is not for human consumption, veterinary diagnostic, or therapeutic use. Statements regarding the biochemical potential of GLP-3 Retatrutide 5mg have not been evaluated by the Food and Drug Administration (FDA). Researchers must follow established laboratory safety protocols.
