NAD+ 500mg

🧪 NAD+ 500mg: Metabolic Research Profile

Nicotinamide Adenine Dinucleotide (NAD+) is a fundamental coenzyme found in all living cells, serving as a primary scaffold for metabolic research. Unlike synthetic analogues, NAD+ is a naturally occurring dinucleotide that functions as a critical redox cofactor. Researchers investigating NAD+ 500mg focus on its ability to modulate the NAD+/NADH ratio, which serves as a metabolic sensor for the redox state of the cell and regulates energy flux through the citric acid cycle.

• Redox Cofactor Dynamics: The NAD+ 500mg coenzyme is primarily researched for its role as an electron acceptor in glycolysis and the Krebs cycle, facilitating the conversion of nutrients into cellular energy (ATP).

• Sirtuin-Mediated Metabolic Regulation: Studies on NAD+ 500mg indicate it is a mandatory substrate for SIRT1 and SIRT3, which regulate mitochondrial biogenesis and lipid metabolism through the deacetylation of key metabolic enzymes.

• ADP-Ribosyltransferase Activity: The NAD+ 500mg formulation is investigated for its consumption by CD38 and PARP enzymes, which impacts systemic NAD+ availability and influences metabolic signaling pathways.

• Mitochondrial Homeostasis: Laboratory evaluations of NAD+ 500mg explore its role in the “mitochondrial-nuclear communication” pathway, essential for maintaining metabolic health during cellular stress.

🔬 Key Research Applications of NAD+ 500mg

This specific NAD+ 500mg concentration is a primary focus for research models investigating:

• 🧬 Metabolic Syndrome Signaling: Investigations into how NAD+ replenishment affects insulin sensitivity and lipid profiles in animal models of metabolic dysfunction.

• 🧠 Bioenergetic Flux: Research into NAD+ 500mg includes evaluations of the mitochondrial respiratory chain efficiency and the prevention of metabolic “bottlenecks” in high-energy tissues.

• 🛡️ Oxidative Stress Modulation: Investigations into the biochemical properties of NAD+ 500mg focus on its capacity to bolster antioxidant defenses by maintaining the pool of NADPH.

• 🔥 Thermogenesis & Energy Expenditure: Evaluation of NAD+ 500mg for its influence on brown adipose tissue (BAT) activation and the regulation of basal metabolic rate.

✅ NAD+ 500mg Product Specifications

❄️ NAD+ 500mg Product Care & Handling Guidelines

Proper storage is essential to prevent the hydrolytic degradation of the NAD+ 500mg coenzyme into nicotinamide and ADP-ribose.

• Unreconstituted (Powder): Store NAD+ 500mg in a desiccated environment. Long-term storage is optimal at -20°C to maintain biochemical stability for up to 2 years.

• Reconstituted (Liquid): Refrigerate NAD+ 500mg at 2°C to 8°C. Because NAD+ is highly sensitive to aqueous degradation, researchers typically prepare fresh solutions or use them within 24–48 hours for maximum experimental accuracy.

• Handling Note: NAD+ is sensitive to pH extremes and light. Use buffered solutions to maintain a pH of approximately 7.0–7.5 and avoid prolonged exposure to intense light sources.

📚 References & Resources

• NCBI PubMed: NAD+ Metabolism and its Role in Metabolic Diseases

• NCBI PMC: NAD+ in Mitochondrial Homeostasis

• NCBI PubMed: Sirtuins as Metabolic Regulators

• PubChem: Nicotinamide Adenine Dinucleotide (NAD+) Compound Summary

• NCBI PubMed: Therapeutic Potential of NAD+ Augmentation

⚠️ Laboratory Research Use Only Notice

The NAD+ 500mg product is strictly intended for in vitro and non-clinical laboratory research purposes only. It is not for human consumption, veterinary diagnostic, or therapeutic use. Statements regarding the metabolic potential of NAD+ 500mg have not been evaluated by the FDA. Researchers must follow established laboratory safety and ethical standards.