🧪 PT-141 10mg: Neurochemical Research Profile
The PT-141 10mg (sequence: Ac-Nle-cyclo-OH) is a synthetic derivative of Melanotan II that has been deaminated to specialize its research applications. Researchers utilizing PT-141 10mg focus on its ability to cross the blood-brain barrier effectively and target the medial preoptic area (mPOA) of the hypothalamus, which is a key region for regulating autonomic and behavioral responses.
Melanocortin Receptor Agonism: The PT-141 10mg peptide is primarily researched for its potent activation of MC3R and MC4R, which triggers intracellular cyclic AMP production in neural analogs.
Dopaminergic System Influence: Studies on PT-141 10mg indicate that it may stimulate the release of dopamine from presynaptic neurons, facilitating research into the excitatory pathways of the central nervous system.
C-Fos Expression Induction: The PT-141 10mg formulation is investigated for its role in upregulating c-Fos immunoreactivity, a standard marker for neuronal activation in the paraventricular nucleus.
Vascular Dynamics Research: Laboratory evaluations of PT-141 10mg explore its centrally-mediated effects on hemodynamics compared to localized nitric oxide pathways.
🔬 Key Research Applications of PT-141 10mg
This specific PT-141 10mg peptide is a primary focus for research models investigating:
🧬 Sexual Dysfunction Signaling: Investigations into the effects of PT-141 10mg on erectile activity and libido modulation in both male and female animal analogs.
🧠 Hypothalamic Circuitry: Research into PT-141 10mg includes evaluations of the mPOA and paraventricular nuclei regarding their role in sexual motivation and arousal.
🛡️ CNS Response Analysis: Investigations into the biochemical properties of PT-141 10mg focus on its capacity to modulate neurobehavioral patterns without causing peripheral blood pressure spikes.
🔥 Reward Pathway Homeostasis: Evaluation of PT-141 10mg for its influence on neurotransmitter balance, particularly dopamine and norepinephrine levels, in response to physiological stimuli.
✅ PT-141 10mg Product Specifications
| Specification | Detail |
| Product Name | PT-141 10mg |
| Molecular Formula | C50H68N14O10 |
| Molecular Weight | 1025.2 g/mol |
| Concentration | 10 mg per vial |
| Sequence | Ac-Nle-cyclo(-Asp-His-D-Phe-Arg-Trp-Lys)-OH |
| Appearance | White lyophilized powder |
| Solubility | Soluble in sterile water or PBS |
❄️ PT-141 10mg Product Care & Handling Guidelines
Proper storage is required to maintain the molecular integrity of the PT-141 10mg heptapeptide.
Unreconstituted (Powder): Store PT-141 10mg in a dry environment. Long-term storage is optimal at -20 degrees C for up to 3 years.
Reconstituted (Liquid): Refrigerate PT-141 10mg at 2 degrees C to 8 degrees C immediately; researchers typically use the solution within 7 to 14 days for maximum potency.
Handling Note: Peptides like PT-141 10mg are sensitive to light and mechanical stress. Use gentle swirling during reconstitution and avoid repeated freeze-thaw cycles.
📚 References & Resources
NCBI PubMed: https://pubmed.ncbi.nlm.nih.gov/12851303/
NCBI PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC2694735/
NCBI PubMed: https://pubmed.ncbi.nlm.nih.gov/14999221/
PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/bremelanotide
NCBI PubMed: https://pubmed.ncbi.nlm.nih.gov/33455598/
⚠️ Laboratory Research Use Only Notice
The PT-141 10mg product is strictly intended for in vitro and non-clinical laboratory research purposes only. It is not for human consumption, veterinary diagnostic, or therapeutic use. Statements regarding the biochemical potential of PT-141 10mg have not been evaluated by the FDA. Researchers must follow established laboratory safety and ethical standards.
