🧪 Sermorelin 5mg: Endocrine Research Profile
The Sermorelin 5mg (sequence: Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2) is a synthetic polypeptide and known GHRH analog.3 Researchers utilizing Sermorelin 5mg focus on its unique ability to stimulate the pituitary gland to produce more growth hormone (GH) while maintaining the body’s natural negative feedback mechanisms.4
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Pulsatile Pituitary Signaling: The Sermorelin 5mg peptide is primarily researched for its ability to trigger episodic, pulsatile growth hormone release, mimicking natural endocrine rhythms rather than creating the “square wave” elevations seen with direct GH administration.5
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GHRH Receptor Agonism: Studies on Sermorelin 5mg indicate that it binds with high specificity to GHRH receptors, activating the intracellular adenylate cyclase-cAMP signaling pathway in somatotropic cells.6
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IGF-1 Modulation Research: The Sermorelin 5mg formulation is investigated for its role in stimulating secondary hepatic production of Insulin-like Growth Factor-1, which facilitates research into anabolic processes and tissue regeneration.
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Metabolic Signaling: Laboratory evaluations of Sermorelin 5mg explore its capacity to induce lipolysis and improve nitrogen balance in waste-state models.
🔬 Key Research Applications of Sermorelin 5mg
This specific Sermorelin 5mg peptide is a primary focus for research models investigating:
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🧬 Musculoskeletal Homeostasis: Investigations into the effects of Sermorelin 5mg on accelerating the repair of connective tissues, preserving lean muscle mass, and evaluating bone mineral density.
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🏃 Physical Performance Signaling: Research into Sermorelin 5mg includes evaluations of aerobic reserve, strength preservation, and the mitigation of age-related physical decline.
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🛡️ Circadian Rhythm & Sleep: Investigations into the biochemical properties of Sermorelin 5mg focus on its capacity to improve deep REM sleep and support cognitive processing speed under stress.
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🔥 Endocrine Diagnostic Models: Evaluation of Sermorelin 5mg for its efficacy as a diagnostic agent to assess the functional capacity of the pituitary-growth hormone axis.
✅ Sermorelin 5mg Product Specifications
| Specification | Detail |
| Product Name | Sermorelin 5mg |
| Molecular Formula | C149H246N44O42S |
| Molecular Weight | 3357.9 g/mol |
| Concentration | 5 mg per vial |
| Sequence | GHRH (1-29) NH2 |
| Appearance | White to off-white lyophilized powder |
| Solubility | Soluble in sterile water or PBS (1 mg/ml) |
❄️ Product Care & Handling Guidelines
Proper storage is required to maintain the molecular integrity of the Sermorelin 5mg polypeptide synthesis.7
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Unreconstituted (Powder): Store the Sermorelin 5mg in a dry, dark environment. Long-term storage is optimal at -20 degrees C to -80 degrees C.
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Reconstituted (Liquid): Mixed Sermorelin 5mg solution is susceptible to rapid degradation; researchers typically refrigerate at 2 degrees C to 8 degrees C and use the solution within 2 to 7 days.
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Handling Note: Peptides in the Sermorelin 5mg synthesis are sensitive to mechanical stress. Use gentle swirling during reconstitution and avoid repeated freeze-thaw cycles.
📚 References & Resources
NCBI PubMed: https://pubmed.ncbi.nlm.nih.gov/11735244/
NCBI PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC2699646/
PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Sermorelin
NCBI PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC4830873/
NCBI PubMed: https://pubmed.ncbi.nlm.nih.gov/18046908/
⚠️ Laboratory Research Use Only Notice
The Sermorelin 5mg product is strictly intended for in vitro and non-clinical laboratory research purposes only. It is not for human consumption, veterinary diagnostic, or therapeutic use. Statements regarding the biochemical potential of Sermorelin 5mg have not been evaluated by the FDA. Researchers must follow established laboratory safety and ethical standards.
