🧪 Tesamorelin 10mg: Endocrine Research Profile
Tesamorelin 10mg is a synthetic polypeptide consisting of 44 amino acids, sharing structural homology with native human GHRH.3 Researchers utilizing Tesamorelin 10mg focus on its unique N-terminal modification, which improves its pharmacokinetics and resistance to dipeptidyl peptidase IV (DPP-IV) degradation compared to endogenous hormones.
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GHRH Receptor Agonism: The Tesamorelin 10mg peptide is primarily researched for its ability to bind to the GHRH-R, triggering the adenylate cyclase-cAMP signaling pathway in somatotrophs.
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Pulsatile GH Secretion: Studies on Tesamorelin 10mg indicate that it promotes the pulsatile release of endogenous growth hormone, which facilitates research into natural secretion patterns versus continuous exposure.4
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IGF-1 Modulation: The Tesamorelin 10mg formulation is investigated for its role in stimulating liver production of Insulin-like Growth Factor-1, a key mediator of anabolic cellular processes.
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Lipolytic Signaling: Laboratory evaluations of Tesamorelin 10mg explore its capacity to induce visceral lipolysis and improve lipid metabolism markers in animal models.5
🔬 Key Research Applications of Tesamorelin 10mg
This specific Tesamorelin 10mg peptide is a primary focus for research models investigating:
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🧬 Visceral Adipose Remodeling: Investigations into the effects of Tesamorelin 10mg on reducing ectopic fat deposits and stabilizing metabolic parameters in models of lipodystrophy.
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🏃 Lean Muscle Dynamics: Research into Tesamorelin 10mg includes evaluations of skeletal muscle area and density, as well as the preservation of lean tissue during wasting states.6
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🛡️ Cardiovascular Metabolic Markers: Investigations into the biochemical properties of Tesamorelin 10mg focus on its influence on triglyceride levels and carotid intima-media thickness.
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🧠 Neurocognitive Pathways: Evaluation of Tesamorelin 10mg for its potential to modulate brain function and support neurocognitive performance in aging or inflammatory models.
✅ Tesamorelin 10mg Product Specifications
| Specification | Detail |
| Product Name | Tesamorelin 10mg |
| Molecular Formula | C221H366N72O67S |
| Molecular Weight | 5135.86 g/mol |
| Concentration | 10 mg per vial |
| Sequence | 44-amino acid sequence with N-terminal modification |
| Appearance | White to off-white lyophilized powder |
| Solubility | Soluble in sterile water or PBS |
❄️ Product Care & Handling Guidelines
Proper storage is required to maintain the molecular integrity of the Tesamorelin 10mg polypeptide synthesis.
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Unreconstituted (Powder): Store Tesamorelin 10mg in a dry, dark environment. Long-term storage is optimal at -20 degrees C to -80 degrees C.
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Reconstituted (Liquid): Mixed Tesamorelin 10mg solution is highly unstable; researchers typically use the solution immediately or discard any unused portion after 24 hours if refrigerated at 2 degrees C to 8 degrees C.
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Handling Note: Peptides like Tesamorelin 10mg are sensitive to mechanical stress and light. Use gentle swirling during reconstitution and avoid repeated freeze-thaw cycles.
📚 References & Resources
NCBI PubMed: https://pubmed.ncbi.nlm.nih.gov/19243281/
NCBI PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC3038486/
NCBI PubMed: https://pubmed.ncbi.nlm.nih.gov/24054930/
PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Tesamorelin
NCBI PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC6766405/
⚠️ Laboratory Research Use Only Notice
The Tesamorelin 10mg product is strictly intended for in vitro and non-clinical laboratory research purposes only. It is not for human consumption, veterinary diagnostic, or therapeutic use. Statements regarding the biochemical potential of Tesamorelin 10mg have not been evaluated by the Food and Drug Administration (FDA). Researchers must follow established laboratory safety and ethical guidelines.
